Een nieuwe studie uitgevoerd door wetenschappers van de Wake Forest University School of Medicine suggereert dat een mediterraan ketogeen dieet, rijk aan gezonde vetten en koolhydraatarme eiwitten, het risico op de ziekte van Alzheimer zou kunnen verminderen. De onderzoekers ontdekten dat dit dieet leidde tot significante veranderingen in het darmmicrobioom en een biologische route die verband houdt met de ziekte van Alzheimer, voornamelijk door de niveaus van gamma-aminoboterzuur (GABA) en GABA-producerende microben te verlagen, terwijl de niveaus van modulerende GABA werden verhoogd. bacteriën, wat mogelijke voordelen suggereert voor de gezondheid van de hersenen en de preventie van dementie.
Wetenschappers van de Wake Forest University School of Medicine hebben een studie gepubliceerd die suggereert dat het volgen van een ketogeen dieet in mediterrane stijl mogelijk kan verminderen[{” attribute=””>Alzheimer’s disease risk.
The researchers conducted a comparison between a low-fat diet and a modified Mediterranean ketogenic diet, which consists of healthful fats/protein and a lower carbohydrate intake. Their findings revealed that this modified diet brought about significant alterations in a biological pathway associated with Alzheimer’s disease.
The findings were recently published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.
According to the Alzheimer’s Association, more than 6.5 million Americans are living with Alzheimer’s disease, and 1 in 3 seniors die with the disease or another form of dementia.
“We hope that better understanding this complex relationship between diet, cognitive status, and gut health will lead to new interventions to prevent and treat Alzheimer’s disease,” said Suzanne Craft, Ph.D., professor of gerontology and geriatric medicine at Wake Forest University School of Medicine.
Suzanne Craft, Ph.D., professor of gerontology and geriatric medicine at Wake Forest University School of Medicine. Credit: Wake Forest University School of Medicine
This study builds upon previous research from Craft’s team showing that a modified ketogenic diet may prove beneficial in the prevention of cognitive decline.
The randomized, single-site study involved 20 adults, nine diagnosed with mild cognitive impairment (MCI) and 11 with normal cognition. These participants were randomly assigned to follow either the low-carbohydrate modified Mediterranean-ketogenic diet or a low-fat, higher carbohydrate diet for six weeks then, after a six-week “washout” period, to switch to the other diet.
Stool samples were collected from participants at the beginning and end of each diet period, and six weeks after the washout of the second diet to analyze changes in gut microbiome—the good and bad bacteria that live in the gastrointestinal tract.
Researchers found that participants with MCI on the modified Mediterranean ketogenic diet had lower levels of gamma-aminobutyric
Reference: “Effects of a ketogenic and low-fat diet on the human metabolome, microbiome, and foodome in adults at risk for Alzheimer’s disease” by Amanda Hazel Dilmore, Cameron Martino, Bryan J. Neth, Kiana A. West, Jasmine Zemlin, Gibraan Rahman, Morgan Panitchpakdi, Michael J. Meehan, Kelly C. Weldon, Colette Blach, Leyla Schimmel, Rima Kaddurah-Daouk, Pieter C. Dorrestein, Rob Knight, Suzanne Craft and the Alzheimer’s Gut Microbiome Project Consortium, 5 April 2023, Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.
DOI: 10.1002/alz.13007
The study was funded by the Wake Forest Alzheimer’s Disease Research Center, the Hartman Family Foundation, Roena B. Kulynych Center for Memory and Cognition Research, and the National Institute on Aging.
